If the test is positive, please refer the patient into one of the NMOSD centres. Establishing the diagnosis of neuromyelitis optica (NMO) and related disorders, including relapsing transverse myelitis or relapsing optic neuritis. If another obvious and definite diagnosis is present.
Unexplained ‘encephalitis’ and seizures with brain lesions.
‘Atypical MS’ or other uncharacterized CNS demyelination. MOG antibodies were originally thought to be involved in multiple sclerosis (MS), but subsequent studies found it to. MOG is a glycoprotein uniquely expressed in oligodendrocytes in the CNS. Recurrent, bilateral or severe optic neuritis Longitudinal or recurrent transverse myelitis A: Myelin oligodendrocyte glycoprotein antibody disorders (MOGAD) is an idiopathic, inflammatory, demyelinating disease of the central nervous system (CNS). Keywords: Anti-MOG, neuromyelitis optica, autoimmunity, demyelinating diseases. azathioprine) may need to be used much like we treat AQP4 antibody associated NMOSD. Turkish Journal of Neurology published by Galenos Publishing House. If a relapse occurs then additional immunosuppressants (e.g. Since we are not sure about the natural course of the disease, treatment usually consists of a slow taper of corticosteroids (prednisolone) over 6 months to a year after the first event. optic neuritis) and MOG antibodies often have a ‘one-off’ event and usually recover well from their illness Treatment of MOG antibody associated disease In contrast to typical NMOSD (caused by AQP4 antibodies) up to half of the persons with an episode of demyelination (e.g. MOG antibodies are found on the myelin sheath rather than the astrocyte as in AQP4 antibodies and cause damage to the myelin. However, their discovery is recent and there is much to be learned. Myelin oligodendrocyte glycoprotein (MOG)-IgG with an NMO spectrum disorder like phenotype is now recognized as a sensitive and specific diagnostic antibody. MOG antibodies have been reported in some people who have transverse myelitis and/or optic neuritis and/or ADEM (acute disseminated encephalomyelitis) and AQP4 antibody negative NMOSD. MOG stands for Myelin Oligodendrocyte Glycoprotein. MOG antibodies MOG antibody-associated demyelination and NMOSD
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